Do all your summers rhyme with tired, heavy legs?
Then turn to Circuvits!
Circuvits is a dietary supplement containing a patented grape-seed extract, Leucoselect®, which has been widely proven on the market to promote venous circulation[1]. In fact, this extract, which is highly titrated in OPC, is the one found in Endotelon, where the efficacy of the Leucoselect® phytosome in combating damage caused by oxidative stress and in cardiovascular protection has been demonstrated by several experimental in vivo studies and confirmed by numerous clinical trials[2].
Its combination with Centella extract boosts its stimulating action on blood microcirculation[3]. The formula is also complemented by bilberry extract, rich in antioxidants, recognised by the EMA to have a protective effect on blood vessels at doses of 160 mg per day or more[4;5]. The addition of vitamin E boosts this shielding effect[6], while vitamin C helps strengthen the collagen-based vein walls[7].
Health claims
√ Grape seeds help support venous circulation;
√ Centella helps to maintain a feeling of light legs;
√ Vitamin C contributes to the normal formation of collagen for the normal functioning of blood vessels;
√ Vitamin E helps protect cells against oxidative stress.
Benefits of the formula
√ Patented grape-seed extract, Leucoselect®, in phytosome form, which ensures total protection of OPCs offering the highest possible bioavailability on the market [8];
√ Rich in antioxidants :
Anthocyanins, oligoproanthocyanidins, vitamin E & vitamin C;
√ Patented vitamin C (PureWay-C™) in the form of liposomes, which increases the absorption kinetics and cellular retention of vitamin C[9];
√ 100% natural & vegetable galenic form (pullulan).
Studies
[1] Paitel D (1981). Rheographic and thermographic study of the effects on peripheral hemodynamics of an endotheoliotrophic, double blind versus placebo study. Vie Medicale 11:776-783. [2] Delacroix (1981). Double-blind trial of Endotelon in chronic venous insufficiency. Revue de Medecine27/28:1793-1802. [3] Cesarone MR, Laurora G, De Sanctis MT, Incandela L, Grimaldi R, Marelli C, Belcaro G, The microcirculatory activity of Centella Asiatica in venous insufficiency. A double-blinded study, Minerva Cardioangiologica [1994, 42(6):299-304]. [4] Williamson G, Manach C. Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am J Clin Nutr. 2005 Jan;81(1 Suppl):243S-255S. Review. [5] Agence européenne des médicaments (2015a). Rapport d'évaluation sur Vaccinium Myrtillus L., Fructus Recens et Vaccinium Myrtillus L., Fructus Siccus . EMA/HMPC/555161/2013Disponible https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-vaccinium-myrtillus-l-fructus-recens-vaccinium-myrtillus-l -fructus-siccus_en.pdf. [6] Louisy F. Action des radicaux libres oxygénés sur les parois veineuses. Nutritions 2004, 6, 21-25. [7] Guide des compléments alimentaires, Vidal, 2008. [8] Gabetta B., et al., Fitoterapia 71, 162 (2000). [9] Weeks BS, Perez PP : Taux d'absorption et valeurs de piégeage des radicaux libres des métabolites lipidiques de la vitamine C dans les cellules lymphoblastiques humaines. Med Sci Monit, 2007 ; 13(10) : BR205-210
